Autologous fibroblast transplantation in the treatment of chronic ulcers

Abstract

Fibroblasts are mesenchymal cells that secrete various growth factors and cytosines and have a direct effect on epidermal proliferation, differentiation and extracellular matrix formation. Due to these properties, autologous fibroblast transplantation has been suggested in several countries (Iran, Italy, Australia, United States) to facilitate the healing of ulcers. In addition to speeding up the cure of them, the health costs for their treatment are reduced. However, although the revised evidence seems to suggest that positive results can be expected from this treatment, the small number of human studies and the small number of patients included in the studies is not sufficient to establish a recommendation. Therefore, it is necessary to increase the amount of research to examine the efficacy and possible complications of this transplant in the long term, evaluate its effect on different types of ulcers and wounds and analyze its possible synergistic effect with other treatments. In this way, healthcare professionals can offer their patients the best care based on the latest evidence.